HuagongsheHuagongshe Chemistry Print Report · For research reference only
Adenine → 2-(6-Aminopurin-9-yl)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Adenine | HCID 190 | — |
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Ethylene carbonate | HCID 7303 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(6-Aminopurin-9-yl)ethanol | HCID 242652 | — |
Reaction Steps
Adenine (9.1 g), ethylene carbonate (6.0 g), and sodium hydroxide (0.14 g) in DMF (68 ml) were heated at reflux for 2 hr. The solution was cooled to 0°, then 70 ml of toluene were added. After sitting for 2 hr at 0°, the precipitate was collected, rinsed with 100 ml of toluene, then cold ethanol, and dried to afford N9 -hydroxyethyladenine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05686629 |
| Source dataset | uspto-grants-1997_11 |
| ORD ID | ord-dc12819a9736481c9acb57e3eabff96c |
| Source note | uspto-grants-1997_11 |