2,4-Dimethoxybenzoyl chloride → HCID 69065748, compound

HRID 229389Notes

Reaction equation

HRID 229389 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[CH:8][C:4]=1[C:5](Cl)=[O:6].[Br:14][C:15]1[CH:16]=[C:17]2[C:22](=[CH:23][CH:24]=1)[N:21]1[CH:25]=[CH:26][CH:27]=[C:20]1[CH:19]([CH3:28])[NH:18]2>>[Br:14][C:15]1[CH:16]=[C:17]2[C:22](=[CH:23][CH:24]=1)[N:21]1[CH:25]=[CH:26][CH:27]=[C:20]1[CH:19]([CH3:28])[N:18]2[C:5](=[O:6])[C:4]1[CH:8]=[CH:9][C:10]([O:12][CH3:13])=[CH:11][C:3]=1[O:2][CH3:1]

Participants

3

Reactant 2

HCID 27347192,4-Dimethoxybenzoyl chlorideHCID 69069638HCID 69069638, compound

Product 1

HCID 69065748HCID 69065748, compound

Procedure

7-Bromo-5-(2,4-dimethoxybenzoyl)-4-methyl-4,5-dihydropyrrolo[1,2-a]quinoxaline was prepared from 2,4-dimethoxybenzoyl chloride and 7-bromo-4-methyl-4,5-dihydropyrrolo[1,2-a]quinoxaline (see Example 106, Step 1) according to the procedure of Example 106, Step 2. The product was purified via Biotage Horizon® (25S, silica, gradient from 5% EtOAc/hexane to 40% EtOAc/hexane) and isolated as a white foam. MS (ESI) m/z 427/429 ([M+H]+); HRMS: calcd for C21H19BrN2O3, 426.0579; found (ESI+), 427.0642.

Workup

  1. customThe product was purified via Biotage Horizon® (25S, silica, gradient from 5% EtOAc/hexane to 40% EtOAc/hexane)
  2. customisolated as a white foam

Sources & evidence

ORD record
ord-e3c717dda1014166b4aa8a4d72339cff
Source dataset
uspto-grants-2009_07
Patent number
US07563793B2

Reaction notes

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