p-Anisoyl chloride → HCID 69066846, compound

HRID 229390Notes

Reaction equation

HRID 229390 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]1[CH:12]=[CH:13][CH:14]=[C:7]1[CH:6]([CH2:15][CH3:16])[NH:5]2.[C:17](Cl)(=[O:26])[C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]1[CH:12]=[CH:13][CH:14]=[C:7]1[CH:6]([CH2:15][CH3:16])[N:5]2[C:17](=[O:26])[C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 7477p-Anisoyl chlorideHCID 69067438HCID 69067438, compound

Product 1

HCID 69066846HCID 69066846, compound

Procedure

7-Bromo-4-ethyl-5-(4-methoxybenzoyl)-4,5-dihydropyrrolo[1,2-a]quinoxaline was prepared from 7-bromo-4-ethyl-4,5-dihydropyrrolo[1,2-a]quinoxaline (see Example 42) and p-anisoyl chloride according to the procedure of Example 106, Step 2. The product was purified via Biotage Horizon® (25S, silica, gradient from 5% EtOAc/hexane to 40% EtOAc/hexane) and isolated as a white foam. MS (ESI) m/z 411/413 ([M+H]+); HRMS: calcd for C21H19BrN2O2, 410.0630; found (ESI+), 411.06959.

Workup

  1. customThe product was purified via Biotage Horizon® (25S, silica, gradient from 5% EtOAc/hexane to 40% EtOAc/hexane)
  2. customisolated as a white foam

Sources & evidence

ORD record
ord-efef2f03ae5f4e33bf5f596de63182c0
Source dataset
uspto-grants-2009_07
Patent number
US07563793B2

Reaction notes

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