Dimethyl malonate → HCID 178516639, compound

HRID 2293909Notes

Reaction equation

HRID 2293909 reaction equation
F[C:2]1[CH:10]=[CH:9][C:8](OC)=[CH:7][C:3]=1[C:4]([NH2:6])=[NH:5].[C:13](OC)(=[O:19])[CH2:14][C:15](OC)=[O:16]>CS(C)=O>[C:3]1([C:4]2[N:5]=[C:15]([OH:16])[CH:14]=[C:13]([OH:19])[N:6]=2)[CH:2]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 7943Dimethyl malonateHCID 21473026HCID 21473026, compound

Product 1

HCID 178516639HCID 178516639, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

A mixture of 2-Fluoro-5-methoxybenzamidine (10.3 g) and dimethyl malonate (8.09 g) in dry dimethyl sulfoxide (7 mL) was allowed to stand at room temperature for 24 h. The precipitated product was collected and washed with water and ether to afford 2-Phenyl-4.6-dihydroxy-pyrimidine as a white solid.

Workup

  1. customThe precipitated product was collected
  2. washwashed with water and ether

Sources & evidence

ORD record
ord-a895e7d102c8444095e5486056a00b95
Source dataset
uspto-grants-1997_11
Patent number
US05688654

Reaction notes

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