Nitric Acid → HCID 178491819, compound

HRID 2293910Notes

Reaction equation

HRID 2293910 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[C:10]1[N:15]=[C:14]([OH:16])[CH:13]=[C:12]([OH:17])[N:11]=1.[N+:18]([O-])([OH:20])=[O:19]>C(O)(=O)C.O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[C:10]1[N:11]=[C:12]([OH:17])[C:13]([N+:18]([O-:20])=[O:19])=[C:14]([OH:16])[N:15]=1

Participants

5

Reactant 2

HCID 944Nitric AcidHCID 178491818HCID 178491818, compound

Product 1

HCID 178491819HCID 178491819, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

To a suspension of 2-(2-Fluoro-5-methoxyphenyl)-4.6-dihydroxy-pyrimidine (12 g) in 35 mL of acetic acid is added 12 mL of 90% nitric acid and the mixture is heated at 50° C. for 45 min. The reaction mixture is diluted with 150 mL of water and the product is collected, washed with water and ethanol and oven dried to afford 2-(2-Fluoro-5-methoxyphenyl)-5-nitro-4.6-dihydroxy-pyrimidine as a pink solid.

Workup

  1. customthe product is collected
  2. washwashed with water and ethanol and oven
  3. customdried

Sources & evidence

ORD record
ord-84044861fffa4de0ba196a10fb5bf468
Source dataset
uspto-grants-1997_11
Patent number
US05688654

Reaction notes

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