Hexylamine → HCID 10457142, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of compound 6 (23.5 mg, 0.059 mmol) and n-hexylamine (1 mL) was heated for 4.5 days at 80° C. After evaporation of volatiles, the residue was purified by preparative TLC (chloroform-methanol, 20:1) to give compound 14 (23.5 mg, 86.0%). 1H NMR (DMSO-d6) δ 0.84 (m, 3 H, CH3), 1.25 (m, 6 H, CH2), 1.45 (m, 2 H, CH2), 3.17 (m, 2 H, CH2), 3.54 (s, 3 H, 9-CH3), 4.58 (br s, 2 H, CH2), 6.32 (br s, 1 H, exchangeable with D2O, NH), 7.09 (pseudo t, J=7.8 and 7.6 Hz, 1 H, H-16), 7.35 (d, J=7.8 Hz, 1 H, H-17), 7.57 (d, J=7.7 Hz, 1 H, H-15), 7.66 (s, 1 H, H-13), 7.71 (s, 1 H, H-8), 7.82 (br s, 1 H, exchangeable with D2O, NH).

Provenance & Evidence