Sodium Chloride → HCID 10024998, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of N6 -(3-iodobenzyl)adenine (2, 50 mg, 140 μmol), 4-bromobutyronitrile (300 mg, 2.0 mmol), and potassium carbonate (150 mg, 1.1 mmol) in DMF (2 mL) was stirred for 12 h at 80° C. Following the addition of 10 mL of half saturated sodium chloride, an oil separated. The oil was chromatographed on a preparative silica TLC plate (chloroform:methanol, 95:5, Rf 0.31) to give compound 22 (40 mg, 66%). MS (EI) m/z 418 (M+), 350, 291, 232, 187.

Provenance & Evidence