2,4-Dimethoxybenzoyl chloride → HCID 69066043, compound

HRID 229393Notes

Reaction equation

HRID 229393 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]1[CH:12]=[CH:13][CH:14]=[C:7]1[CH:6]([C:15]([CH3:18])([CH3:17])[CH3:16])[NH:5]2.[CH3:19][O:20][C:21]1[CH:29]=[C:28]([O:30][CH3:31])[CH:27]=[CH:26][C:22]=1[C:23](Cl)=[O:24]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]1[CH:12]=[CH:13][CH:14]=[C:7]1[CH:6]([C:15]([CH3:18])([CH3:17])[CH3:16])[N:5]2[C:23](=[O:24])[C:22]1[CH:26]=[CH:27][C:28]([O:30][CH3:31])=[CH:29][C:21]=1[O:20][CH3:19]

Participants

3

Reactant 2

HCID 27347192,4-Dimethoxybenzoyl chlorideHCID 690626917-Bromo-4-tert-butyl-4,5-dihydropyrrolo[1,2-a]quinoxaline

Product 1

HCID 69066043HCID 69066043, compound

Procedure

7-Bromo-4-tert-butyl-5-(2,4-dimethoxybenzoyl)-4,5-dihydropyrrolo[1,2-a]quinoxaline was prepared from 7-bromo-4-tert-butyl-4,5-dihydropyrrolo[1,2-a]quinoxaline (see Example 114, Step 1) and 2,4-dimethoxybenzoyl chloride according to the procedure of Example 106, Step 2. The product was purified via Biotage Horizon® (25S, silica, gradient from 5% EtOAc/hexane to 40% EtOAc/hexane) and isolated as a white foam. MS (ESI) m/z 469/471 ([M+H]+); HRMS: calcd for C24H25BrN2O3, 468.1049; found (ESI+), 469.11175.

Workup

  1. customThe product was purified via Biotage Horizon® (25S, silica, gradient from 5% EtOAc/hexane to 40% EtOAc/hexane)
  2. customisolated as a white foam

Sources & evidence

ORD record
ord-d0499e2b55a54ff682b2991967d7545d
Source dataset
uspto-grants-2009_07
Patent number
US07563793B2

Reaction notes

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