1-(2-Pyrimidinyl)piperazine → HCID 484843, compound

HRID 2293974Notes

Reaction equation

HRID 2293974 reaction equation
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10](F)[C:11]=2[O:13][CH:14]([F:16])[F:15])[C:6](=[O:18])[C:5]([C:19]([OH:21])=[O:20])=[CH:4]1)[CH3:2].[N:22]1[CH:27]=[CH:26][CH:25]=[N:24][C:23]=1[N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1>>[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([N:31]3[CH2:32][CH2:33][N:28]([C:23]4[N:22]=[CH:27][CH:26]=[CH:25][N:24]=4)[CH2:29][CH2:30]3)[C:11]=2[O:13][CH:14]([F:16])[F:15])[C:6](=[O:18])[C:5]([C:19]([OH:21])=[O:20])=[CH:4]1)[CH3:2]

Participants

3

Reactant 2

HCID 887471-(2-Pyrimidinyl)piperazineHCID 21473338HCID 21473338, compound

Product 1

HCID 484843HCID 484843, compound

Procedure

The same reaction as in Example 1 was carried out by using 1-ethyl-7-fluoro-8-difluoromethoxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid and 1-(2-pyrimidinyl)piperazine to obtain the title compound as white powder.

Workup

  1. customThe same reaction as in Example 1

Sources & evidence

ORD record
ord-1954c6ca424541769cc025815d79cc00
Source dataset
uspto-grants-1997_11
Patent number
US05688791

Reaction notes

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