HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 2,4,5-Trifluoro-3-difluoromethoxybenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3-(Difluoromethoxy)-2,4,5-trifluorobenzoic acid | HCID 15023781 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2,4,5-Trifluoro-3-difluoromethoxybenzoyl chloride | HCID 15282971 | — |
Reaction Steps
To 36.0 g (0.15 mole) of 2,4,5-trifluoro-3-difluoromethoxybenzoic acid were added 45 ml of toluene, 15 ml of thionyl chloride and 0.2 ml of N,N-dimethylformamide, and the mixture was refluxed by heating for 4 hours. After the reaction, toluene and excess thionyl chloride were removed under reduced pressure to obtain 2,4,5-trifluoro-3-difluoromethoxybenzoyl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05688791 |
| Source dataset | uspto-grants-1997_11 |
| ORD ID | ord-68eb6bab692349878ea0158cf00b1e6d |
| Source note | uspto-grants-1997_11 |