Hydrochloric Acid → 5-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-2-methyl-pyrimidin-4-ylamine dihydrochloride

HRID 2294007노트

반응식

HRID 2294007 반응식
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][N:2]1[CH2:11][C:12]1[C:13]([NH2:19])=[N:14][C:15]([CH3:18])=[N:16][CH:17]=1.[ClH:20]>CO>[ClH:20].[ClH:20].[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][N:2]1[CH2:11][C:12]1[C:13]([NH2:19])=[N:14][C:15]([CH3:18])=[N:16][CH:17]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 214736575-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-2-methyl-pyrimidin-4-ylamine

생성물 1

HCID 214737105-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-2-methyl-pyrimidin-4-ylamine dihydrochloride수율 40.7%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 0.70 g (0.00275 mol) of 5-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-2-methyl-pyrimidin-4-ylamine in 15 ml of methanol was treated with 0.85 ml (0.00435 mol) of 3.5N ethanolic hydrochloric acid. The solution was completely freed from the solvents and the residue was recrystallized from methanol. 0.29 g (32%) of 5-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)-2-methyl-pyrimidin-4-ylamine dihydrochloride was obtained as white crystals; m.p. 260°-265°.

후처리

  1. customthe residue was recrystallized from methanol

출처 및 근거

ORD 기록
ord-071234b36ec148a19f53415b5c74fcd9
출처 데이터셋
uspto-grants-1997_11
특허 번호
US05688798

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