Triethylamine → HCID 70193092, compound

Participants

Reaction Steps

A suspension of 0.195 g (0.0010 mol) of 5-chloromethyl-2-methyl-pyrimidin-4-ylamine in 5 ml of dimethylformamide was treated with 0.42 ml (0.0030 mol) of triethylamine and 0.365 g (0.0010 mol) of 1,2,3,4-tetrahydro-pyridin-4-ylmethyl benzoate and the mixture was stirred at room temperature under argon for 18 hours. The solvent was distilled off in a high vacuum. The residue was partitioned between dichloromethane/water, extracted and dried over MgSO4. After removing the solvent the residue was chromatographed over silica gel with ethyl acetate as the eluent. 0.17 g (74%) of 1-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-1,2,3,6-tetrahydro-pyridin-4-ylmethyl benzoate was obtained as a yellow oil. MS (ISP): me/e=339 (C19 H23N4O2+).

Provenance & Evidence