Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 2-Methyl-5-(4-phenethyl-piperazin-1-ylmethyl)-pyrimidin-4-ylamine hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 2-Methyl-5-(4-phenethyl-piperazin-1-ylmethyl)-pyrimidin-4-ylamine | HCID 21473614 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-Methyl-5-(4-phenethyl-piperazin-1-ylmethyl)-pyrimidin-4-ylamine hydrochloride | HCID 21473713 | 87% |
반응 단계
A solution of 0.37 g (0.0012 mol) of 2-methyl-5-(4-phenethyl-piperazin-1-ylmethyl)-pyrimidin-4-ylamine in 20 ml of methanol was treated with 0.37 ml (0.00129 mol) of 3.5N ethanolic hydrochloric acid, The solution was completely freed from the solvents and the residue was recrystallized from ethanol. 0.36 g (87%) of 2-methyl-5-(4-phenethyl-piperazin-1-ylmethyl)-pyrimidin-4-ylamine hydrochloride (1:1.2) was obtained as white crystals; m.p. 240°-242°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05688798 |
| 출처 데이터셋 | uspto-grants-1997_11 |
| ORD ID | ord-00c4f20c742949b193696e7c20ead8da |
| 출처 메모 | uspto-grants-1997_11 |