HCID 21473602, compound → HCID 21473635, compound

Participants

Reaction Steps

A suspension of 0.040 g of platinum dioxide in 2 ml of tetrahydrofuran was treated with a solution of 0.11 g (0.00034 mol) of [5-(4-benzyloxymethyl-3,6-dihydro-2H-pyridin-1-ylmethyl)-2-methyl-pyrimidin-4-yl]-amine in 3.5 ml of tetrahydrofuran and the mixture was hydrogenated under normal pressure for 5 hours. The catalyst was filtered off, the filtrate was concentrated and the residue was chromatographed on silica gel with ethyl acetate as the eluent. 0.078 g (70%) of [5-(4-benzyloxymethyl-piperidin-1-ylmethyl)-2-methyl-pyrimidin-4-yl]-amine was obtained as colourless crystals; m.p. 106°-108°.

Provenance & Evidence