HCID 68801526, compound → HCID 178452560, compound

HRID 229403Notes

Reaction equation

HRID 229403 reaction equation
[C:1]([O:5][C:6]([N:8]1[C:12]2=[N:13][C:14]([O:17][C:18]3[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:19]=3[F:25])=[N:15][CH:16]=[C:11]2[C:10]([O:26]C(OC(C)(C)C)=O)=[N:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>N.CO>[C:1]([O:5][C:6]([N:8]1[C:12]2=[N:13][C:14]([O:17][C:18]3[CH:23]=[CH:22][C:21]([F:24])=[CH:20][C:19]=3[F:25])=[N:15][CH:16]=[C:11]2[C:10]([OH:26])=[N:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 68801526HCID 68801526, compound

Product 1

HCID 178452560HCID 178452560, compound

Reagents, catalysts & solvents 2

HCID 222AmmoniaSolventHCID 887MethanolSolvent

Procedure

3-tert-Butoxycarbonyloxy-6-(2,4-difluoro-phenoxy)-pyrazolo[3,4-d]pyrimidine-1-carboxylic acid tert-butyl ester was dissolved in a solution of NH3 in methanol (6 mL, 2 M) and stirred at room for 12 hours. The mixture was concentrated under reduced pressure to give 190 mg of 6-(2,4-difluoro-phenoxy)-3-hydroxy-pyrazolo[3,4-d]pyrimidine-1-carboxylic acid tert-butyl ester as a white solid residue that was used without purification in the next step.

Workup

  1. concentrationThe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-770173a6f0894932920ea51e341febba
Source dataset
uspto-grants-2009_07
Patent number
US07563800B2

Reaction notes

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