2-Bromopropane → HCID 68802502, compound

Participants

Reaction Conditions

Reaction Steps

6-(2,4-Difluoro-phenoxy)-3-hydroxy-pyrazolo[3,4-d]pyrimidine-1-carboxylic acid tert-butyl ester (190 mg, 0.52 mmol) was mixed with K2CO3 (144 mg, 1 mmol) and isopropyl bromide (0.29 mL, 5.2 mmol) in DMF (3 mL). The mixture was heated at 40° C. for 4 hours, then cooled and diluted with water. The resulting mixture was extracted with EtOAc and the combined organic fractions were dried over MgSO4, filtered and concentrated under reduced pressure. The residue was purified with flash column chromatography flushing with 30% ethyl acetate in hexanes to give 190 mg of 6-(2,4-difluoro-phenoxy)-3-isopropoxy-pyrazolo[3,4-d]pyrimidine-1-carboxylic acid tert-butyl ester.

Provenance & Evidence