Ammonia → HCID 178514712, compound

Participants

Reaction Steps

4-Chloro-3-[6-(2,4-difluoro-phenoxy)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-benzenesulfonyl chloride (34 mg, 0.735 mmol) was added to a solution of 2M NH3 in MeOH (1 mL), and the reaction mixture was stirred for 20 minutes. The reaction mixture was concentrated under reduced pressure, and the residue was purified by preparative TLC (40% EtOAc in hexanes) to give 15 mg of 4-chloro-3-[6-(2,4-difluoro-phenoxy)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-benzenesulfonamide, MS (M+H)=418.

Provenance & Evidence