Hydrogen Bromide → HCID 21473473, compound

Participants

Reaction Steps

A mixture of 1-(2,4-dimethoxyphenyl) piperazine hydrochloride (3.1 g, 13.9 mmol) in 30 mL of approximately 40% aqueous hydrogen bromide was heated at reflux for 30 hours and then the volatiles were removed in vacuo. Recrystallization of the residue from methanol gave 1-(4-hydroxy-2-methoxyphenyl)piperazine dihydrobromide (4.6 g, 12.4 mmol), m.p. >280° C.

Provenance & Evidence