HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetate → 8-{2-[1-(2,6-dimethyl-benzyl)-cyclopropylamino]-1-hydroxy-ethyl}-5-hydroxy-4H-benzo[1,4]oxazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetate | HCID 84468 | — |
| Reactant | 1-[(2,6-Dimethylphenyl)methyl]cyclopropan-1-amine | HCID 23106106 | — |
| Reactant | 5-(benzyloxy)-8-(dihydroxyacetyl)-2H-1,4-benzoxazin-3(4H)-one | HCID 23106148 | — |
| Product | 8-{2-[1-(2,6-dimethyl-benzyl)-cyclopropylamino]-1-hydroxy-ethyl}-5-hydroxy-4H-benzo[1,4]oxazin-3-one | HCID 11603360 | — |
Reaction Steps
The compound is prepared according to general method 3 from 329 mg (1 mmol) 5-benzyloxy-8-(2,2-dihydroxy-acetyl)-4H-benzo[1,4]oxazin-3-one and 175 mg (1 mmol) 1-(2,6-dimethyl-benzyl)-cyclopropylamine. Yield: 52 mg (11%, trifluoroacetate); mass spectroscopy: [M+H]+=383.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07563806B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-f875085d69c547b39e64965929c69e92 |
| Source note | uspto-grants-2009_07 |