HCID 21473507, compound → HCID 21473455, compound

HRID 2294156Notes

Reaction equation

HRID 2294156 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N:10]1[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][NH:19][C:20]2[CH:30]=[CH:29][C:28]([CH3:31])=[CH:27][C:21]=2[C:22]([N:24]([CH3:26])[CH3:25])=[O:23])[CH2:12][CH2:11]1)([O-])=O>[Pd].C(O)C>[NH2:1][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[N:10]1[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][NH:19][C:20]2[CH:30]=[CH:29][C:28]([CH3:31])=[CH:27][C:21]=2[C:22]([N:24]([CH3:26])[CH3:25])=[O:23])[CH2:12][CH2:11]1

Participants

4

Reactant 1

HCID 21473507HCID 21473507, compound

Product 1

HCID 21473455HCID 21473455, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 2-{3-[4-(2-nitrophenyl)piperazin-1-yl]propylamino}-N,N,5-trimethylbenzamide (580 mg, 1.36 mmol), prepared as in Example 26, and 10% palladium on carbon (70 mg) in 15 mL of ethanol was added and stirred under hydrogen at room temperature for approximately 12 hours. The mixture was filtered and concentrated to give 2-{3-[4-(2-aminophenyl)piperazin-1-yl]propyl-amino}-N,N,5-trimethylbenzamide.

Workup

  1. additionwas added
  2. filtrationThe mixture was filtered
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-f2f8e5262eae4cfcbeaaa8191fc80483
Source dataset
uspto-grants-1997_11
Patent number
US05688795

Reaction notes

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