Nitric Acid → HCID 21474087, compound

HRID 2294191Notes

Reaction equation

HRID 2294191 reaction equation
[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([C:8](=[O:15])[NH:9][C:10](=[O:14])[NH:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[N+:16]([O-])([OH:18])=[O:17]>>[N+:16]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:4]=1[N+:1]([O-:3])=[O:2])[NH:11][C:10](=[O:14])[NH:9][C:8]2=[O:15])([O-:18])=[O:17]

Participants

3

Reactant 2

HCID 944Nitric AcidHCID 33981137-NITROQUINAZOLINE-2,4(1H,3H)-DIONE

Product 1

HCID 21474087HCID 21474087, compoundYield 59%

Procedure

10 g (48.3 mmol) of 7-nitro-1,2,3,4-tetrahydro-quinazoline-2,4-dione were added portionwise at 0° C. to 32 ml of fuming nitric acid. Thereafter, the mixture was stirred at room temperature for a further 5 hrs. The reaction mixture was poured on to ice, the precipitate was filtered off under suction and washed with 65% nitric acid, dilute nitric acid and finally with water. 7.15 g (59%) of 6,7-dinitro-1,2,3,4-tetrahydroquinazoline-2,4-dione were obtained as a yellow powder;

Workup

  1. additionThe reaction mixture was poured on to ice
  2. filtrationthe precipitate was filtered off under suction
  3. washwashed with 65% nitric acid, dilute nitric acid and finally with water

Sources & evidence

ORD record
ord-58eac6daefbb4c7581d2368c6af2d754
Source dataset
uspto-grants-1997_11
Patent number
US05688803

Reaction notes

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