HCID 21473963, Verbindung → HCID 178518842, Verbindung

HRID 2294199Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2294199
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[NH:13][NH:12][C:11](=[O:14])[C:10]=1[C:15]([O:17]CC)=O>CN(C)C=O>[Cl:8][C:6]1[CH:5]=[CH:4][C:3]2[C:9]3[NH:13][NH:12][C:11](=[O:14])[C:10]=3[C:15]([OH:17])=[N:1][C:2]=2[CH:7]=1

Komponenten

3

Edukt 1

HCID 21473963HCID 21473963, Verbindung

Produkt 1

HCID 178518842HCID 178518842, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

3.1 g (0.011 mol) of ethyl 5-(2-amino-4-chloro-phenyl)-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate were dissolved in 30 ml of dimethylformamide and boiled under reflux for 2 hrs. The mixture was concentrated, the residue was suspended in 150 ml of methanol at reflux, cooled, suction filtered and dried in a vacuum. Yield: 1.1 g (42%) of 7-chloro-4-hydroxy-2,3-dihydro-1H-pyrazolo[4,3-c]quinolin-3-one as brownish crystals; m.p. >350° C.

Aufarbeitung

  1. temperatureunder reflux for 2 hrs
  2. concentrationThe mixture was concentrated
  3. temperatureat reflux
  4. temperaturecooled
  5. filtrationsuction filtered
  6. customdried in a vacuum

Quellen und Nachweise

ORD-Eintrag
ord-ba3a791ad2604edeb137ad4d2e40e87d
Quelldatensatz
uspto-grants-1997_11
Patentnummer
US05688803

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