Trifluoroacetate → HCID 11595811, compound

HRID 229423Notes

Reaction equation

HRID 229423 reaction equation
C([O:8][C:9]1[C:14]2[NH:15][C:16](=[O:19])[CH2:17][O:18][C:13]=2[C:12]([C:20](=[O:24])[CH:21](O)O)=[CH:11][CH:10]=1)C1C=CC=CC=1.[NH2:25][C:26]1([CH2:29][C:30]2[CH:35]=[CH:34][C:33]([N:36](CC3C=CC=CC=3)CC3C=CC=CC=3)=[CH:32][CH:31]=2)[CH2:28][CH2:27]1.FC(F)(F)C([O-])=O>>[NH2:36][C:33]1[CH:32]=[CH:31][C:30]([CH2:29][C:26]2([NH:25][CH2:21][CH:20]([C:12]3[C:13]4[O:18][CH2:17][C:16](=[O:19])[NH:15][C:14]=4[C:9]([OH:8])=[CH:10][CH:11]=3)[OH:24])[CH2:27][CH2:28]2)=[CH:35][CH:34]=1

Participants

4

Reactant 3

HCID 84468TrifluoroacetateHCID 23106098N-[4-[(1-Aminocyclopropyl)methyl]phenyl]-N-(phenylmethyl)benzenemethanamineHCID 231061485-(benzyloxy)-8-(dihydroxyacetyl)-2H-1,4-benzoxazin-3(4H)-one

Product 1

HCID 11595811HCID 11595811, compound

Procedure

Prepared according to general method 3 from 329 mg (1 mmol) 5-benzyloxy-8-(2,2-dihydroxy-acetyl)-4H-benzo[1,4]oxazin-3-one and 342 mg (1 mmol) [4-(1-amino-cyclopropylmethyl)-phenyl]-dibenzyl-amine. Yield: 49 mg (10%, trifluoroacetate); mass spectroscopy: [M+H]+=370.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-f3d25d7b7ec44801a62efc24e5ade6d2
Source dataset
uspto-grants-2009_07
Patent number
US07563806B2

Reaction notes

Loading…