HCID 21474294, compound → HCID 21474381, compound

Participants

Reaction Steps

2.14 g of 3-benzyloxy-1-(2-hydroxy-ethyl)-2-(hydroxy-phenyl-methyl)-1H-pyridin-4-one (Example 1d) are hydrogenated in 200 ml of methanol over 0.5 g of palladium on carbon (5%) under normal pressure and at a temperature of 50° C. until 2 mol of H2 per mol of starting material have been taken up. The catalyst is removed by filtration and the filtrate is concentrated by evaporation using a rotary evaporator. The residue is recrystallised from ethanol, yielding 2-benzyl-3-hydroxy-1-(2-hydroxy-ethyl)-1H-pyridin-4-one in the form of colourless crystals. M.p.: 228°-230° C.

Provenance & Evidence