HCID 21474269, compound → HCID 21474460, compound

HRID 2294245Notes

Reaction equation

HRID 2294245 reaction equation
C([O:8][C:9]1[C:14](=[O:15])[CH:13]=[CH:12][N:11]([CH3:16])[C:10]=1[CH:17]([OH:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)C1C=CC=CC=1>CO.[Pd]>[OH:8][C:9]1[C:14](=[O:15])[CH:13]=[CH:12][N:11]([CH3:16])[C:10]=1[CH:17]([OH:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

4

Reactant 1

HCID 21474269HCID 21474269, compound

Product 1

HCID 21474460HCID 21474460, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Under normal pressure and at room temperature, 0.643 g of 3-benzyloxy-1-methyl-2-(hydroxy-phenyl-methyl)-1H-pyridin-4-one is hydrogenated in 25 ml of methanol over 0.1 g of palladium on carbon (5%) until 1 mol of H2 per mol of starting material has been taken up. Removal of the catalyst and recrystallisation from methanol yield 3-hydroxy-1-methyl-2-(hydroxy-phenyl-methyl)-1H-pyridin-4-one. M.p.: 210°-213° C.

Workup

  1. customat room temperature
  2. customRemoval of the catalyst and recrystallisation from methanol

Sources & evidence

ORD record
ord-5ae4fa9e04fd4dedb16ad5ee60e3d9b7
Source dataset
uspto-grants-1997_11
Patent number
US05688815

Reaction notes

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