HCID 21474257, compound → HCID 21474389, compound

HRID 2294247Notes

Reaction equation

HRID 2294247 reaction equation
C([O:8][C:9]1[C:14](=[O:15])[CH:13]=[CH:12][N:11]([CH2:16][CH2:17][OH:18])[C:10]=1[CH:19]([OH:26])[C:20]1[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=1)C1C=CC=CC=1>CO>[OH:8][C:9]1[C:14](=[O:15])[CH:13]=[CH:12][N:11]([CH2:16][CH2:17][OH:18])[C:10]=1[CH:19]([OH:26])[C:20]1[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 1

HCID 21474257HCID 21474257, compound

Product 1

HCID 21474389HCID 21474389, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

At room temperature and under normal pressure, 0.6 g of 3-benzyloxy-1-(2-hydroxy-ethyl)-2-(hydroxy-pyridin-3-yl-methyl)-1H-pyridin-4-one are hydrogenated in 20 ml of methanol until 1 mol of H2 per mol of starting material has been taken up. The catalyst is removed by filtration and the flitrate is concentrated to dryness by evaporation. The residue is recrystallised from methanol, yielding 3-hydroxy-1-(2-hydroxy-ethyl)-2-(hydroxy-pyridin-3-yl-methyl)-1H-pyridin-4-one in the form of colourless crystals, m.p.: 189°-190.5° C.

Workup

  1. customAt room temperature
  2. customThe catalyst is removed by filtration
  3. concentrationthe flitrate is concentrated to dryness by evaporation
  4. customThe residue is recrystallised from methanol

Sources & evidence

ORD record
ord-d4509ef810f442cd8060d0e60a99c478
Source dataset
uspto-grants-1997_11
Patent number
US05688815

Reaction notes

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