HCID 21474355, compound → HCID 21474322, compound

Participants

Reaction Steps

Under normal pressure and at room temperature, 1.1 g of 3-benzyloxy-2-[(4-benzyloxy-3-methoxy-phenyl)-hydroxy-methyl]-1-(2-hydroxy-ethyl)-1H-pyridin-4-one are hydrogenated in 50 ml of methanol over 0.2 g of palladium on carbon (5%) until 2 mol of H2 per mol of starting material have been taken up. Removal of the catalyst and recrystallisation from ethanol yield 3-hydroxy-1-(2-hydroxy-ethyl)-2-[hydroxy-(4-hydroxy-3-methoxy-phenyl)-methyl]-1H-pyridin-4-one. M.p.: 179°-190° C.

Provenance & Evidence