HCID 178492508, compound → HCID 178492509, compound

Participants

Reaction Steps

0.9 g of 3-benzyloxy-2-[(4-benzyloxy-3-methoxy-phenyl)-hydroxy-methyl]-pyridin-4-ol is dissolved in 100 ml of methanol and hydrogenated at room temperature in the presence of 0.18 g of palladium on carbon (5%) until 2 mol of H2 per mol of starting material have been taken up. The catalyst is removed by filtration and the flitrate is concentrated by evaporation. Recrystallisation from methanol yields 2-[hydroxy-(4-hydroxy-3-methoxy-phenyl)-methyl]-pyridine-3,4-diol. Colourless crystals, m.p.: from 210° C. with decomposition.

Provenance & Evidence