Hydrochloric Acid → HCID 21474457, compound

Participants

Reaction Conditions

Reaction Steps

1.9 ml of 37% conc. HCl are poured over 0.19 g of 3-benzyloxy-1-(2-hydroxy-ethyl)-2-[hydroxy-(4-nitro-phenyl)-methyl]-1H-pyridin-4-one. The mixture is heated with stirring at 100° C. for 45 minutes. 20 ml of toluene are added and distillation is carried out at a bath temperature of 50° C. and under a pressure of 60 mbar using a rotary evaporator. The addition of toluene and the distillation are repeated four times. The crystalline residue is recrystallised from ethanol, yielding 3-hydroxy-1-(2-hydroxy-ethyl)-2-[hydroxy-(4-nitro-phenyl)-methyl]-1H-pyridin-4-one hydrochloride. Brown crystals, m.p.: from 204° C. with decomposition.

Provenance & Evidence