Hydrochloric Acid → HCID 21474314, compound

Participants

Reaction Conditions

Reaction Steps

26 ml of 37% conc. HCl are poured over 2.65 g of 3-benzyloxy-1-(2-hydroxy-ethyl)-2-[hydroxy-(4-chloro-phenyl)-methyl]-1H-pyridin-4-one and the reaction mixture is heated with stirring at 110° C. for 10 minutes. After cooling, 100 g of ice are added. With stirring and cooling in an ice-bath, the reaction mixture is neutralised with approximately 22 ml of conc. sodium hydroxide solution to a pH of 6.5. 50 ml of ethyl acetate are added and stirring is carried out at room temperature for 4 hours. The resulting product is filtered off and washed with water and ethyl acetate, yielding 2-[(4-chloro-phenyl)-hydroxy-methyl]-3-hydroxy-1-(2-hydroxy-ethyl)-1H-pyridin-4-one. M.p.: 184°-186° C.

Provenance & Evidence