HCID 21474427, compound → HCID 21474323, compound

Participants

Reaction Steps

0.266 g of 5-benzyloxy-6-[(4-fluoro-phenyl)-hydroxy-methyl]-1-(2-hydroxy-ethyl)-4-oxo-1,4-dihydro-pyridine-2-carboxylic acid are dissolved in 20 ml of methanol and hydrogenated at room temperature over 0.05 g of palladium on carbon (5%) until 1 mol of H2 per mol of starting material has been taken up. The catalyst is removed by filtration and the flitrate is concentrated to dryness by evaporation using a rotary evaporator. Recrystallisation from methanol yields 6-[(4-fluoro-phenyl)-hydroxy-methyl]-7-hydroxy-3,4-dihydro-pyrido[2,1-c]-[1,4]oxazine-1,8-dione in the form of colourless crystals. M.p.: 221°-225° C.

Provenance & Evidence