HCID 86751618, compound → HCID 21474334, compound

Participants

Reaction Steps

2.2 g of acetic acid [1-(2-acetoxy-ethyl)-3-benzyloxy-4-oxo-1,4-dihydropyridin-2-yl-methyl]-phenyl-methyl ester are hydrogenareal in 50 ml of tetrahydrofuran over 0.5 g of palladium on carbon (5%) under normal pressure and at a temperature of 50° C. until 2 mol of H2 per mol of starting material have been taken up. The catalyst is removed by filtration and the flitrate is concentrated by evaporation using a rotary evaporator. Recrystallisation from tetrahydrofuran yields 2-benzyl-3-hydroxy-1-(2-acetoxy-ethyl)-1H-pyridin-4-one, Colourless crystals, m.p.: 139.7°-140.7° C.

Provenance & Evidence