Ethanolamine → HCID 21474406, compound

HRID 2294261Notes

Reaction equation

HRID 2294261 reaction equation
C(OC1C(=O)C=COC=1[CH:16]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[F:30])[O:17][CH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][O:19]1)C1C=CC=CC=1.[CH2:31]([CH2:33][NH2:34])[OH:32]>C(O)C>[CH2:16]([O:32][C:31]1[C:18](=[O:17])[CH:23]=[CH:22][N:34]([CH2:21][CH2:20][OH:19])[C:33]=1[CH:16]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[F:30])[O:17][CH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][O:19]1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

Participants

4

Reactant 2

HCID 700EthanolamineHCID 21474252HCID 21474252, compound

Product 1

HCID 21474406HCID 21474406, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3-Benzyoxy-1-(2-hydroxy-ethyl)-2-[-2-fluorophenyl)-(tetrahydro-pyran-2-yloxo)-methyl]-1H-pyridin-4oone: 5.66 g of 3-benzyloxy-2-[(2-fluorophenyl)-(tetrahydro-pyran-2-yloxy)-methyl]-pyran-4-one are boiled under reflux for 24 hours in 50 ml of ethanol and 10 ml of ethanolamine. Working-up analogously to Example 1c yields 3-benzyloxy-1-(2-hydroxy-ethyl)-2-[(2-fluorophenyl)-(tetrahydro-pyran-2-yloxy)-methyl]-1H-pyridin-4-one in the form of a semi-crystalline yellow mass. Rf value: 0.2 (silica gel 60, ethyl acetate/ethanol 9/1).

Sources & evidence

ORD record
ord-a6c18f0c4ebb4e0e80392ea5ac282b2b
Source dataset
uspto-grants-1997_11
Patent number
US05688815

Reaction notes

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