Ammonia → HCID 21474336, compound

HRID 2294263Notes

Reaction equation

HRID 2294263 reaction equation
[OH:1][C:2]1[C:7](=[O:8])[CH:6]=[CH:5][N:4]([CH2:9][CH2:10][O:11]C(=O)C)[C:3]=1[CH2:15][C:16]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=1.N>CO>[OH:1][C:2]1[C:7](=[O:8])[CH:6]=[CH:5][N:4]([CH2:9][CH2:10][OH:11])[C:3]=1[CH2:15][C:16]1[CH:17]=[CH:18][C:19]([F:22])=[CH:20][CH:21]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 86751619HCID 86751619, compound

Product 1

HCID 21474336HCID 21474336, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

2.0 g of acetic acid 2-[3-hydroxy-2-(4-fluorobenzyl)-4-oxo-4H-pyridin-1-yl]-ethyl ester dissolved in 20 ml of methanol, and 5 ml of a 6M solution of ammonia in methanol are added. The reaction solution is stirred at room temperature for 18 hours, the product precipitating in the form of a thick crystal mass. Filtering, washing with methanol and drying yield 3-hydroxy-1-(2-hydroxy-ethyl)-2-(4-fluorobenzyl)-1H-pyridin-4-one in the form of colourless crystals. M.p.: 225°-231° C., decomp. from 190° C.

Workup

  1. customthe product precipitating in the form of a thick crystal mass
  2. filtrationFiltering
  3. washwashing with methanol
  4. customdrying

Sources & evidence

ORD record
ord-0c780c3bfe49402cb1ea4fc6005cc10b
Source dataset
uspto-grants-1997_11
Patent number
US05688815

Reaction notes

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