HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Amino-2-phenylthio-2-propanol → 5-{4-[2-(3-Phenylthio-2-hydroxypropylamino)propoxy]benzyl}thiazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Amino-2-phenylthio-2-propanol | HCID 113732 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 5-[4-(2-Oxopropoxy)benzyl]thiazolidine-2,4-dione | HCID 21832150 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-{4-[2-(3-Phenylthio-2-hydroxypropylamino)propoxy]benzyl}thiazolidine-2,4-dione | HCID 21474787 | 36.3% |
Reaction Steps
A procedure similar to that described in Example 2 was repeated, except that 2.95 g of 3-phenylthio-2-hydroxypropylamine (prepared as described in Preparation 87), 3 g of 5-[4-(2-oxopropoxy)benzyl]thiazolidine-2,4-dione, 1.0 g of sodium cyanoborohydride and 100 ml of anhydrous methanol were used, to give 1.74 g of the title compound, melting at 176° C. to 177° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05688823 |
| Source dataset | uspto-grants-1997_11 |
| ORD ID | ord-db70fcc6f90e43629cdc53b8b2f9681c |
| Source note | uspto-grants-1997_11 |