Dimethylformamide → 5-[4-{2-[5-(N-Methyl-N-phenylaminomethyl)-2-oxooxazolidin-3-yl]propoxy}benzyl]thiazolidine-2,4-dione

Participants

Reaction Steps

A procedure similar to that described in Example 4 was repeated, except that 0.9 g of 5-[4-{2-[3-(N-methyl-N-phenylamino)-2-hydroxypropylamino]propoxy}-benzyl]thiazolidine-2,4-dione (prepared as described in Example 39), 0.36 g of N,N'-carbonyldiimidazole and 20 ml of anhydrous dimethylformamide were used, to give 0.6 g of the title compound having an Rf value of 0.24 (on silica gel thin layer chromatography, using a 1:1 by volume mixture of ethyl acetate and hexane as the developing solvent).

Provenance & Evidence