Tetrabutylammonium Fluoride → 2-[5-(4-Methoxyphenoxymethyl)-2-oxooxazolidin-3-yl]propanol

Participants

Reaction Steps

A procedure similar to that described in Preparation 5(b) was repeated, except that 1.52 g of 3-(2-t-butyldimethylsilyloxy-1-methylethyl)-5-(4-methoxyphenoxymethyl)oxazolidin-2-one (less polar isomer), obtained as described in Preparation 76, 12 ml of tetrabutylammonium fluoride (26% w/v in tetrahydrofuran) and 10 ml of anhydrous tetrahydrofuran were used, to give 1.20 g of the title compound, melting at 80° C. to 88° C., from the less polar diastereomer.

Provenance & Evidence