3-Nitrophenylboronic Acid → HCID 23433671, compound

HRID 2294465Notes

Reaction equation

HRID 2294465 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6](B(O)O)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].Br[C:14]1[CH:20]=[CH:19][C:17]([NH2:18])=[C:16]([Cl:21])[CH:15]=1>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[Cl:21][C:16]1[CH:15]=[C:14]([C:6]2[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=2)[CH:20]=[CH:19][C:17]=1[NH2:18]

Participants

4

Reactant 2

HCID 16773-Nitrophenylboronic AcidHCID 6101694-Bromo-2-chloroaniline

Product 1

HCID 23433671HCID 23433671, compound

Reagents, catalysts & solvents 1

HCID 178418397HCID 178418397, compoundCatalyst

Procedure

This compound was prepared by General Method 14 (EXAMPLE 191) from 3-nitrobenzeneboronic acid (0.25 g, 1.5 mmol), 4-bromo-2-chloroaniline (0.21 g, 1.0 mmol), and (PPh3)4Pd (35 mg, 0.030 mmol) to afford a crude material which was used directly in the next step.

Sources & evidence

ORD record
ord-20858b52ffee43fb9d5a8f41f24f8e15
Source dataset
uspto-grants-1997_11
Patent number
US05688810

Reaction notes

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