HCID 23433509, compound → 2'-Fluoro-5'-methoxy4-nitro-2-biphenylcarboxylic acid

HRID 2294471Notes

Reaction equation

HRID 2294471 reaction equation
FC1C=CC(OC)=C(C2C(C(O)=O)=CC([N+]([O-])=O)=CC=2)C=1.[F:22][C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][C:24]=1[C:31]1[C:32]([C:41]([O:43]C)=[O:42])=[CH:33][C:34]([N+:38]([O-:40])=[O:39])=[CH:35][C:36]=1C>>[F:22][C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][C:24]=1[C:31]1[C:32]([C:41]([OH:43])=[O:42])=[CH:33][C:34]([N+:38]([O-:40])=[O:39])=[CH:35][CH:36]=1

Participants

3

Reactant 2

HCID 23433509HCID 23433509, compoundHCID 234336025'-Fluoro-2'-methoxy-4-nitro-2-biphenylcarboxylic acid

Product 1

HCID 234335282'-Fluoro-5'-methoxy4-nitro-2-biphenylcarboxylic acidYield 103.9%

Procedure

This compound was prepared in a manner similar to that of 5'-fluoro-2'-methoxy-4-nitro-2-biphenylcarboxylic acid (EXAMPLE 107) from methyl 2'-fluoro-5'-methoxy-6-methyl-4-nitro-2-biphenylcarboxylate (0.77 g) to afford 0.73 g (99%) of 2'-fluoro-5'-methoxy-4-nitro-2-biphenylcarboxylic acid as a white solid, which was used in the next step without further purification.

Sources & evidence

ORD record
ord-3bda15571cc4498d8f5b46910cd48da3
Source dataset
uspto-grants-1997_11
Patent number
US05688810

Reaction notes

Loading…