HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 53920798, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Iodoacetyl chloride | HCID 3084680 | — |
| Reactant | 5-Amino-2-hydroxybenzamide | HCID 12325186 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 53920798 | HCID 53920798 | 96% |
Reaction Steps
To an ice-cooled, stirred solution of 5-Aminosalicylamide (10.0 grams, 0.073 mol), in 300 mL of water containing NaHCO3 (42.0 grams, 0.5 mol), iodoacetyl chloride (18.4 grams, 0.09 mol) is added dropwise over 15 min. After stirring at 0°-5° C. for 1 hr., the solution is acidified with cold 6N HCl. The precipitate is collected and dried in vacuo over NaOH pellets, to afford 21.3 grams (96% yield) of crude 5-(iodoacetamido)salicylamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05688928 |
| Source dataset | uspto-grants-1997_11 |
| ORD ID | ord-4f89c4342af0440b817e90fc09911820 |
| Source note | uspto-grants-1997_11 |