Aniline → HCID 137629483, compound

Participants

Reaction Steps

To ethyl 5-bromo-4-(bromomethyl)-2-{[(2-imino-4-oxo-1,3-thiazolidin-5-yl) acetyl]amino}thiophene-3-carboxylate (25 mg, 0.05 mmol) in N,N dimethyl formaide (1 mL) was added aniline (10 mg, 0.11 mmol). The reaction mixture was stirred at room temperature for 16 h. Then the reaction mixture was concentrated and purified by reverse phase column to yield ethyl 4-(anilinomethyl)-5-bromo-2-{[(2-imino-4-oxo-1,3-thiazolidin-5-yl)acetyl]amino}thiophene-3-carboxylate (5.0 mg, 20% yield).

Provenance & Evidence