HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Diethylaniline → HCID 21475298, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Diethylaniline | HCID 7061 | — |
| Reactant | Phenol, 4-aMino-2,6-bis(1,1-diMethylethyl)-, hydrochloride | HCID 12201564 | — |
| Reactant | 7-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE | HCID 12281647 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 21475298 | HCID 21475298 | 40.4% |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
A suspension of 7-chloropyrazolo[1,5-a]pyrimidine (1.0 g), 3,5-di-t-butyl-4-hydroxyaniline hydrochloride (1.8 g) and diethylaniline (2.3 ml) in toluene (50 ml) is heated at 120° C. for 30 minutes. After cooling, the solvent is distilled off, and the residue is purified by silica gel column chromatography (solvent; CHCl3) to give 7-(3,5-di-t-butyl-4-hydroxyphenyl)aminopyrazolo[1,5-a]pyrimidine (890 mg) as colorless crystal.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05688949 |
| Source dataset | uspto-grants-1997_11 |
| ORD ID | ord-87849fe6b5e049e0938ca9418af39b88 |
| Source note | uspto-grants-1997_11 |