Sodium Hydroxide → HCID 21475297, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 7-(2-methoxycarbonylphenyl)amino-5-methylpyrazolo[1,5-a]pyrimidine (1.0 g) prepared in Example 3 in ethanol (20 ml) is added a 5% sodium hydroxide solution (30 ml), and the mixture is heated with stirring at 100° C. for one hour. After cooling, the mixture is evaporated to remove ethanol, and the residue is neutralized with a 10% hydrochloric acid, and further the pH value of the mixture is adjusted to pH 4 with a saturated aqueous citric acid solution. The precipitated crystal is collected by filtration, and washed with water, ethanol and ethyl ether, and dried to give 7-(2-carboxyphenyl)amino-5-methylpyrazolo[1,5-a]pyrimidine (970 mg) as colorless crystal.

Provenance & Evidence