Bromopinacolone → 1-(3-isobutyryl-6-methoxy-1H-indazol-1-yl)-3,3-dimethylbutan-2-one

Participants

Reaction Steps

Reaction of 1-(6-methoxy-1H-indazol-3-yl)-2-methylpropan-1-one with 1-bromo-3,3-dimethylbutan-2-one using a procedure similar to that described in Example 3 Step A gave the title compound. Recrystallization from 2:1 hexanes and EtOAc gave fine needles. 1H NMR (CDCl3, 500 MHz) δ 8.25 (d, 8.9 Hz, 1H), 6.98 (dd, 2.0 & 8.9 Hz, 1H), 6.52 (d, 1.8 Hz, 1H), 5.37 (s, 2H), 3.87 (s, 3H), 3.86 (heptet, 6.9 Hz, 1H), 1.36 (s, 9H), 1.27 (d, 6.8 Hz, 6H). LC-MS: 3.70 min. (m/Z=317.1, 339.1).

Provenance & Evidence