HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → N-(3,3-Dimethylbutyl)-N-ethyl-2-(3-isobutyryl-6-methoxy-1H-indazol-1-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 1-Hydroxybenzotriazole hydrate | HCID 2796029 | — |
| Reactant | (3-Isobutyryl-6-methoxy-1H-indazol-1-yl)acetic acid | HCID 57675517 | — |
| Reactant | N-Ethyl-3,3-dimethylbutan-1-amine hydrochloride | HCID 71374414 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-(3,3-Dimethylbutyl)-N-ethyl-2-(3-isobutyryl-6-methoxy-1H-indazol-1-yl)acetamide | HCID 68854854 | — |
Reaction Steps
Charge a 13×100 mm screw-capped tube with 27.6 mg (3-isobutyryl-6-methoxy-1H-indazol-1-yl)acetic acid, 23.0 mg HOBt hydrate, 18.6 mg N-ethyl-3,3-dimethylbutan-1-amine hydrochloride, and 89 μL DIEA. Dissolve the mixture in 1 mL anhydrous DMF. Add 38.3 mg EDC HCl salt and let the mixture sit at room temperature overnight. The title compound was isolated from the reaction mixture using RP-HPLC with 65-100% MeCN gradient with 0.1% TFA. LC-MS: 3.89 min. (m/Z=388.2, 410.1)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07563816B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-bce0574aed2d4222b53431a1eb8c78d8 |
| Source note | uspto-grants-2009_07 |