Water → HCID 12762576, compound

Participants

Reaction Steps

Water (20 ml) and potassium carbonate (10.64 g) were added to a solution of benzyl dibenzyloxyacetate (11.15 g, prepared as described in Step 1 above) in tetrahydrofuran (80 ml) and the mixture heated under reflux for twenty-four hours. It was allowed to cool, poured into water, extracted with ether, acidified with concentrated hydrochloric acid and again extracted with ether. The extract from acidic solution was washed with brine, dried over magnesium sulphate and evaporated under reduced pressure to give the title compound (8.12 g), used crude in Step 3.

Provenance & Evidence