Sodium Hydroxide → HCID 21475335, compound

Participants

Reaction Steps

Chloromethyl ethylether (18.1 g) was added dropwise, during 20 minutes, to a vigorously stirred mixture of crude product of Step 1 (21.8 g) dissolved in dichloromethane (50 ml), 52% aqueous sodium hydroxide (34 g) and benzyl triethylammonium chloride (0.2 g), with water-bath cooling to 20° C. After 30 minutes the mixture was treated with saturated aqueous potassium dihydrogen phosphate until pH 8, at 20° C., extracted with dichloromethane (5×100 ml), the extract dried over sodium sulphate, filtered and concentrated under reduced pressure to give the crude product as a yellow oil (27.5 g). 1H NMR (CDCl3): δ 1.23(3 H,t); 2.21(3 H,s); 3.0(2 H,s); 3.68(2 H,bq); 5.1(2H,s); 7.58(4 H,m).

Provenance & Evidence