3-(Trifluoromethoxy)aniline → HCID 21475353, compound

Participants

Reaction Steps

A solution of dibenzyloxyacetic acid (23.1 g) in diethyl ether (200 ml) was added to a solution of 3-trifluoromethoxyaniline (15 g) in diethyl ether (100 ml). A solution of dicyclohexyldicarbodiimide (16.5 g) in diethyl ether (100 ml) was then added in two portions. The mixture was left overnight and the precipitated solid then filtered off and the filtrate diluted with a mixture of diethyl ether and hexane (5:95) and refrigerated for an hour. The solid which separated was collected and washed with hexane, giving the title compound (10 g) with a melting point of 75°-77° C.

Provenance & Evidence