Potassium Persulfate → HCID 86751630, compound

Participants

Reaction Steps

10.2 ml (11 mmol) of 1.08N sodium ethylate solution are added dropwise at 0° to a mixture of 1.99 g (10.47 mmol) of ethyl α-benzylacrylate and 2.26 g (11 mmol) of tert-butyl [2-methyl-2-mercaptopropyl]carbamate in 5 ml of dioxan. Thereafter, the mixture is stirred at 0° for 0.5 hours and at room temperature for 2.5 hours. The reaction mixture is treated while cooling with ice with 8.96 g (14.6 mmol) of potassium monopersulphate triple salt, suspended in 15 ml of water, and stirred at room temperature for 1 hour. Thereafter, the mixture is cooled to 0° and a suspension of 8.96 g (14.6 mmol) of potassium monopersulphate triple salt in 15 ml of water is again added. Subsequently, the mixture is stirred at room temperature for 15 hours. The reaction mixture is diluted with 50 ml of water and the aqueous solution is extracted three times with 50 ml of ether each time. The combined organic solutions are dried over sodium sulphate and evaporated. There are obtained 3.25 g of tert-butyl [2-[[(RS)-2-(ethoxycarbonyl)-3-phenylpropyl]sulphonyl]-2-methylpropyl]carbamate as a colourless oil; MS: 445 (M+NH4)+.

Provenance & Evidence