反应详情

A mixture of 2 g (7 mmol) of (S)-α-[(tert-butylsulphonyl)methyl]hydrocinnamic acid (EPA 0236734) and 2 g of rhodium/aluminium oxide catalyst (5%) in 100 ml of ethanol is hydrogenated for 10 hours at 50° and 10 bar. After filtering off the catalyst the reaction solution is evaporated under reduced pressure and the residue is recrystallized from a 9:1 mixture of hexane and ethyl acetate. There are obtained 1.6 g of (S)-α-[(tert-butylsulphonyl)methyl]cyclohexanepropionic acid as colourless needles; MS: 308 (M+NH4)+.

1. filtrationAfter filtering off the catalyst the reaction solution
2. customis evaporated under reduced pressure
3. customthe residue is recrystallized from a 9:1 mixture of hexane and ethyl acetate